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Biomaterials for Mimicking and Modelling Tumor Microenvironment

Book chapterJournal paper
Rupambika Das, Javier G Fernandez
Advances in experimental medicine and biology 2022. 1379, 139-170
Publication year: 2022


Research in conventional 2D cancer models systematically fails to provide physiological significance due to their discrepancy with diseased tissue’s native complexity and dynamic nature. The recent developments in biomaterials and microfabrication have enabled the popularization of 3D models, displacing the traditional use of Petri dishes and microscope slides to bioprinters or microfluidic devices. These technologies allow us to gather large amounts of time-dependent information on tissue–tissue, tissue–cell, and cell–cell interactions, fluid flows, and biomechanical cues at the cellular level that were inaccessible by traditional methods. In addition, the wave of new tools producing unprecedented amounts of data is also triggering a new revolution in the development and use of new tools for analysis, interpretation, and prediction, fueled by the concurrent development of artificial intelligence. Together, all these advances are crystalizing a new era for biomedical engineering characterized by high-throughput experiments and high-quality data.


Cellulosic Biocomposites for Sustainable Manufacturing

Book chapter
S Dritsas, Y Vijay, S Halim, R Teo, N Sanandiya, Javier G Fernandez
Fabricate 2020, 74-81
Publication year: 2020


Fabricate 2020 is the fourth title in the FABRICATE series on the theme of digital fabrication and published in conjunction with a triennial conference (London, April 2020). The book features cutting-edge built projects and work-in-progress from both academia and practice. It brings together pioneers in design and making from across the fields of architecture, construction, engineering, manufacturing, materials technology and computation. Fabricate 2020 includes 32 illustrated articles punctuated by four conversations between world-leading experts from design to engineering, discussing themes such as drawing-to-production, behavioural composites, robotic assembly, and digital craft.

Microscale Biomaterials for Tissue Engineering

Book chapter
Wheeldon I, Fernandez JG, Bae H, Kaji H, Khademhosseini A.
Springer | Vienna 2011 | 119-138 | ISBN: 978-3-7091-0384-5
Publication year: 2011

9783709103845 (Small)Abstract:

A concise overview of tissue engineering technologies and materials towards specific applications, both past and potential growth areas in this unique discipline is provided to the reader. The specific area of the biomaterial component used within the paradigm of tissue engineering is examined in detail. This is the first work to specifically covers topics of interest with regards to the biomaterial component. The book is divided into 2 sections: (i) general materials technology (e.g., fibrous tissue scaffolds) and (ii) applications in the engineering of specific tissues (e.g., materials for cartilage tissue engineering). Each chapter covers the fundamentals and reflects not only a review of the literature, but also addresses the future of the topic. The book is intended for an audience of researchers in both industry and academia that are interested in a concise overview regarding the biomaterials component of tissue engineering, a topic that is timely and only growing as a field.

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