Azusa and Jason’s paper on ECM-based microchannels demonstrating interstitial flow has been published. We demonstrated to fabricate ECM-based microfluidic devices to mimic interstitial flow through ECM. The interstitial flow allowed controlling the chemical environment at the surface of the hydrogel, which can regulate cellular response.
This work is led by Azusa (Keio U, a former visiting student to SUTD) and Jason. Shun (Keio U) and Rahul contributed to this work. Many thanks to Prof. Onoe for amazing collaboration!
ECM-based microfluidic gradient generator for tunable surface environment by interstitial flow
Biomicrofluidics, 2020, 14, 044106.