Book Chapter on Design and Fabrication of Microfluidic Devices Published

A book chapter on design and fabrication of microfluidic devices is published. We discussed recent progress of fabrication of microfluidic devices with design thinking approach. Congratulations Terry leading another fantastic work, and thanks Yi-Chin for co-supervising!

Design and fabrication of micro/nanofluidics devices and systems
Prog. Mol. Biol. Transl. Sci., 2021, In Press
T Ching, Y-C Toh, and M Hashimoto*

Opinion on Translation of Organ-on-a-chip Platforms Published

An opinion article on the organ-on-a-chip platforms was published in Trends in Pharmacological Sciences (TIPS). This article discussed the recent advance in organ-on-a-chip platforms and their academia-to-industry translation. Terry led the efforts co-supervised by Yi-Chin and Shrike. Congratulations and thank you for the opportunity for this collaboration.

Bridging the academia-to-industry gap: organ-on-a-chip platforms for safety and toxicology assessment
Trends Pharmacol. Sci. 2021, In Press
T Ching, Y-C Toh*, M Hashimoto*, YS Zhang*

Paper on Liquid Metal Antenna Published

Kento’s paper on the liquid metal antenna on the ultra-deformable substrate was published. We developed a liquid-metal-based flexible antenna for tissue-interfaced biomedical applications. Coil-shape microchannels were 3D-printed on a thin elastomeric film and Galinstan (a low toxicity gallium alloy) was infused to achieve a wireless device. The fluidic antenna operates in response to near-field communication frequency (13.56 MHz) under extreme deformation, on wet tissue, or both. We believe the developed flexible antenna finds applications as an implantable and tissue-adhesive wireless platform. Congratulations, Kento, Wenshen, Terry, and the team! Thank you for the amazing collaboration, Professor Huang.

Ultra-Deformable and Tissue-Adhesive Liquid Metal Antennas with High Wireless Powering Efficiency
Adv. Mater, 2021, 2008062
Kento Yamagishi, Wenshen Zhou, Terry Ching, Shao Ying Huang, and Michinao Hashimoto*


Paper on microstructures fabricated by PolyJet printer published

Sindhu’s paper on micromolds fabricated by Polyjet printer is published. The fidelity of Polyjet printing is known to be affected by reflow and spreading of photoresin. In this work, we studied the deviations in both lateral and vertical dimensions of the microstructures printed by PolyJet printers. Crucially, we found the effect on the height of the printed features is prominent when the width of the feature is narrow. This finding should be useful for the design and fabrication of microstructures using PolyJet printers, especially for the fabrication of the mold for microchannels. Congratulations, Sindhu, Pravien and the team!

Evaluation of Lateral and Vertical Dimensions of Micromolds Fabricated by a PolyJet™ Printer
Micromachines, 2021, 12 (3), 302
Sindhu Vijayan, Pravien Parthiban, and Michinao Hashimoto

Paper on 3D-PAD published

James’s paper on 3D paper-based analytical device (3D-PAD) is published. We developed a method to apply fused-deposition modeling 3D printing to integrate 3D features with cellulose-based paper-based fluidic platform. As a demonstration, we have shown such a device can enhance the containment of organic solvents in the paper, which would be difficult in paper-based devices fabricated via solid wax printing. Congratulations, James!

3D-PAD: Paper-Based Analytical Devices with Integrated Three-Dimensional Features
Biosensors 2021, 11 (3), 84
James S. Ng and Michinao Hashimoto

Paper on freeform polymer precipitation published

Rahul’s paper on freeform polymer precipitation (FPP) is published. We developed a method to 3D print freeform structures of thermoplastics in microparticulate gels. The microparticulate gels provided dual functions – physical support and environment for immersion precipitation – that offered support-free 3D-patterning of thermoplastics inks. Congratulations, Rahul!

Freeform Polymer Precipitation in Microparticulate Gels
ACS Appl. Polym. Mater. 2021, 3, 2, 908–919
Rahul Karyappa and Michinao Hashimoto

Related articles:

Paper on DIY Peristaltic Pump Published

Terry’s paper on DIY peristaltic pump is published. We developed DIY fabrication of peristaltic pump combining 3D-printed parts and commercially available components. The developed pump is fairly small and customizable, and fully compatible with the perfusion cell culture in the incubator. The cost of each pump is ~50 USD. Congratulations, Terry and the team!

Great collaboration with the research groups of Prof. Chwee Teck Lim, Prof. Javier G. Fernandez, and Prof. Yi-Chin Toh. Many thanks!

Highly-Customizable 3D Printed Peristaltic Pump Kit
HardwareX, 2021, e00202
Terry Ching, Jyothsna Vasudevan, Hsih Yin Tan, Chwee Teck Lim, Javier Fernandez, Yi-Chin Toh, Michinao Hashimoto

Paper on Preheated Gelatin Printing Published

Justin’s paper on preheating gelatin is published. We demonstrated preheating gelatin extended its 3D printing time compared to freshly prepared gelatin and enhanced the printability of the ink, which is essential for extrusion-based bioprinting and food printing. Congratulations Justin and Cheng Pau!

Preheating of Gelatin Improves its Printability with Transglutaminase in Direct Ink Writing 3D Printing
Int. J. Bioprint., 2020, 6, 4, 296
Justin Jia Yao Tan, Cheng Pau Lee, Michinao Hashimoto

Paper on Interstitial Flow Device Published

Azusa and Jason’s paper on ECM-based microchannels demonstrating interstitial flow has been published. We demonstrated to fabricate ECM-based microfluidic devices to mimic interstitial flow through ECM. The interstitial flow allowed controlling the chemical environment at the surface of the hydrogel, which can regulate cellular response.

This work is led by Azusa (Keio U, a former visiting student to SUTD) and Jason. Shun (Keio U) and Rahul contributed to this work. Many thanks to Prof. Onoe for amazing collaboration!

ECM-based microfluidic gradient generator for tunable surface environment by interstitial flow
Biomicrofluidics, 2020, 14, 044106.