At present, there is much interest in human embryonic stem cells as a starting resource to create functional cells and tissues for regenerative medicine. Clinical applications of human embryonic stem cell therapy can only be possible if the monitoring of replicable human embryonic stem cells can be achieved. We observed a unique bioelectric signal of human embryonic stem cells using direct current−voltage measurements allowed by few-layered two-dimension MoS2 sheets. A 1.828 mA cell signal was achieved, as well as multiple cell reading cycles showing I ∼ 1.9 mA. Native stem cell growth, survivability and replicability were preserved. Computer simulations revealed the origin of the increase in current flow furnished by two-dimension MoS2 sheet. This paves the way for the development of a broadly applicable, fast, and damage-free stem cell detection method capable of identifying replicability with almost any semiconductor circuits.
S. S. Y. Chan, Y.-S. Tan, K.-X. Wu, C. Cheung, and D. K. Loke. Ultra-High Signal Detection of Human Embryonic Stem Cells Driven by Two-Dimensional Materials. ACS Appl. Bio Mater. 1, 210-215 (2018).
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