Research

General Research Direction:
Our group's overarching research theme is microfluidics, both fundamentals and applications. Ongoing research topics include multiphase microfluidics, biomaterials formation, drug delivery, and development of medical and diagnostic devices. We are also interested in reducing the cost of science and technology, and making them accessible to broader range of people. Along this line, our research interest is on low-cost device fabrication and their application in point-of-care setting.

Keywords:
Microfluidics, Biomaterials, Medical Implants, Drug delivery. Self-Assembly, Complexity, Micro/Nano-fabrication.

Our current Research focuses:
1. Low Cost, Unconventional Fabrication of Scientific Tools

We develop a method to create scientific tools utilizing low cost technologies available in general laboratories. We start with the development of microfluidic platform using simple technologies as drawing, cutting, embossing and ink-let printing to prototype and add functionalities to those devices.

2. Point-of-care Diagnostics

We apply the platform developed in 1 for the use of point-of-care diagnostics performed in the field. Specifically, we are interested in the diagnostics of tropical diseases relevant to the context of Singapore and Southeast Asian countries (e.g. Dengue, Malaria etc), in collaboration with clinical partners.

3. Micro/nanotechnologies for Biomaterials and Medical Devices

We apply micro and nanotechnologies for fabrication of biomateirals and functional medical devices. Current focus includes synthesis of micro and nanoparticles using microfluidic methods. We demonstrated the use of flow-focusing technologies for synthesis of drug-loaded, monodisperse microparticles of poly glycolic-co-lactic acid (PLGA) for sustained drug release. The same platform can be used for fabrication of micro- and nanoparticles of various size, shape and compositions. Among others, we are also interested in developing microfabricated, implantable structures that can perform drug delivery and continuous monitoring against specific disease and biomarkers.

4. Anything that you are interested

I like almost anything. Our group is open to initiate any new project—from fundamentals to applied—combining your expertise with those of our lab members. Lab-on-chip, digital (or multiphase) microfluidics, optofluidics are another set of keywords relevant to our focus, but we do not have to limit to them.

There is no such thing as a right thing to do. Let's ask following questions to your new idea.

  • What is new (what is the status quo, what difference do we make)
  • Why it is important (why it is important to find answers to a question we ask and/or to make things we make)
  • Who cares (what is the broad impact of the work, who would use and benefit from the idea and/or technology we generate)

Please bring up any new idea to Prof. Hashimoto. Any idea has potentials to turn into something interesting. I like almost anything, and we can collectively make almost anything interesting.

Fluidics, Soft Matter and Digital Fabrication